It seems to depend on it's mood. Sometimes I can get into setup.
When I have got into setup, the only option I have changed from default is to put in my Astraweb account and password.
Sometimes I can start a download, (if I open it with the .nzb file for what I want to download) but it will stop responding rather quickly, and when I open the program again it has forgotten what it was downloading before it crashed.
The time it takes to crash can vary; sometimes it takes 10 seconds, sometimes 30. I've never had it open for more than a minute without it crashing though.